Struktur Histopatologi Ginjal dan Hati Kambing Penderita Tripanosomiasis Pasca Pengobatan Berenil
AbstractBerenilR (diminazene aceturate) is a chemotrypanocide and commonly used for treatment of protozoa infections as Babesiosis, Leishmaniasis and Trypanosomiasis in large animals. Indonesian government explained that the drug was never used before. Since 1999, Directorate of Livestock Services, Department of Agriculture, Republic of Indonesia recommended that the drug could be used for treatment of Trypanosomes cases. In contrast, the dosage level for the treatment of Trypanosomes was never determined before. In the late 2005, Indonesian researchers have investigated the new dosage of BerenilR for trypanosomes treatment. Base on the problem described above, the study was carried out to evaluate toxic effect of BerenilR to kidneys and livers. The objective of this study was to obtain the new data of toxic effect at multiple dosages. Ten Etawa breed goats were infected by Trypanosoma evansi Bangkalan isolate at more than 3.108Trypanosoma/ml during the week. Five of ten subjects were treated by intramuscularly of BerenilR at multiple doses or superimpose dose (initial dosage 10.44 mg/kg body weight and four times of 7 mg/kg body weight every 31 minutes). Forty five days post treatment; the subjects were killed and the kidneys and livers were removed and preserved in 20% formalin. The histological specimens of their organs stained by haematoxylline eosin (HE) were examined by light microscope. There were no breakage on the histology structure of the Etawa breed goat kidneys and livers after treatment. It could be concluded that the BerenilR at multiple dosages was effective dose for treatment (P < 0.05) of Trypanosomes.
Key words: diminazene aceturate, superimpose, goats, toxic effect, kidney, liver
Download data is not yet available.
Authors submitting manuscripts should understand and agree that copyright of manuscripts published are held by Media Peternakan. The statement to release the copyright to Media Peternakan is stated in Form A. This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License (CC BY-SA) where Authors and Readers can copy and redistribute the material in any medium or format, as well as remix, transform, and build upon the material for any purpose, but they must give appropriate credit (cite to the article or content), provide a link to the license, and indicate if changes were made. If you remix, transform, or build upon the material, you must distribute your contributions under the same license as the original.